Hyperbaric Oxygen Therapy

Hyperbaric cancer

Hypoxia is a critical hallmark of solid tumors and involves enhanced cancer cells survival, angiogenesis, glycolytic metabolism, and metastasis. Hyperbaric oxygen (HBO) treatment has been used for centuries to improve or cure disorders involving hypoxia and ischemia, by enhancing the amount of dissolved oxygen in the plasma and thereby increasing oxygen delivery to the tissue.

Highlights of Hyperbaric Oxygen Therapy

  1. Raises plasma oxygen via gas laws, improving tissue oxygenation markedly
  2. Alleviates tumor hypoxia and enhances the sensitivity of chemotherapy, radiotherapy, and immunotherapy
  3. Modulates oxidative stress, ferroptosis, and tumor microenvironment
  4. Regulates Reactive Oxygen Species (ROS), Mitochondria, and Tumor Microenvironment to inhibit tumor progression
  5. Mitigates radiation-induced tissue injury and improves clinical outcomes in cancer therapy

Cancer & Hypoxia

Hyperbaric Oxygen Cancer

Solid tumors often contain areas of acute or chronic hypoxia. Adaptation to the hypoxic microenvironment allows cancer cells to survive and proliferate. More recently, hypoxia has been proven to be a causative factor in many pathophysiological events, including cancer progression. 

Hyperbaric Oxygen Therapy (HBOT) at Bali’s Health Care Center, offers a unique method to re-oxygenate tumors and remodel the tumor environment by substantially increasing dissolved oxygen in plasma. Pre-clinical and clinical studies revealed that HBOT:

  1. Enhances drug penetration
  2. Augments radiation-induced DNA damage
  3. Alleviates Hypoxia-driven Immunosupression
  4. Synergizes with immune checkpoint blockade

Hyperbaric Oxygen can be used to overcome hypoxia. HBOT administers 100% oxygen at higher than normal atmospheric pressure.

Tumor Hypoxia not only drives resistance to radiotherapy and chemotherapy but also promotes invasion and metastasis via hypoxia-inducible factors (HIFs). HBOT at Bali’s Health Care Center can rapidly elevate intratumoral oxygen levels, therefore enhancing the “oxygen effect” in radiotherapy and improving the penetration of chemotherapeutic medicine.